Key patents associated with VeraTag technology issued by Monogram
2008-07-24 18:37:10 (GMT) (Caymanmama.com - Technology News)San Francisco, California (CaymanMama.com) – Monogram Biosciences, Inc. announced that the three prime United State Patents for proprietary VeraTag technology (United States patent numbers 7,402,397; 7,402,398; 7,402,399) have been issued. The patents are wide and relate with the use of Monogram’s VeraTag technology for the methods of profiling as well as detecting protein complexes including protein heterodimers and homodimers. In addition, the European Patent number 1278760 has been issued as well.
Being able to profile and detect protein complexes is essential since the proteins attain their biological function at the time when they form the protein complexes, interact and in that way, trigger the cellular signaling procedure. Thereby, the protein complexes are crucial in regulating the cellular proliferation and survival in normal as well as abnormal cells.
Exemplars of the protein complexes are those including the same protein coupling up in order to form homodimers and various other proteins coupling to form heterodimers. Being capable of profiling and detecting aberrant and normal protein complexes like the heterodimers and homodimers is considered important for envisaging the patient prognosis and resort to the therapy.
The subjected copyright claims the ways of detecting and profiling the protein complexes are very broad and include all kinds of protein complexes, embracing heterodimers and homodimers, identified with the VeraTag procedure.
Exemplars of the protein complexes included in the patents incorporates complexes engaging the HER or ErbB proteins like HER1 OR EFGR, HER2, HER3 and VEGFR2 (Vascular Endothelial Growth Factor receptors) as well as G-protein paired receptors. Other proteins include Grb2, PI3 Kinase, Rs, SOS, IGF1-R, Raf and AKT and many proteins included in the signal transduction.
William D. Young, Monogram’s Chief Executive Officer said, “The latest issued patents provide patent protection for some of the most important applications of our VeraTag technology — those related to the identification of protein complexes.”
According to Gordon Parry, Ph.D, Monogram’s Vice President of Oncology Research and Development, “Protein complexes are considered to be critical to the mechanisms of action of many cancer drugs.”
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