Cancer Genetics Research - Link found in brain, pancreatic tumors
2008-09-08 13:13:51 (GMT) (Caymanmama.com - Health News News)
Miami, Florida (CaymanMama.com) — According to a revealing set of three studies published in the journals Science and Nature as per the Associated Press, cancer genetics may never look the same again. Researchers of the study have found a potential link between genetic changes and the way that they transform normal cells in the pancreas and brain into two of the most fatal cancers in the body. In addition, the study may have resulted in the creation of a new approach in combating tumor and identifying them faster than ever before.
Typically, a genetic make up is the main culprit for a patient’s cancer diagnosis, however each person’s tumor is different and that makes it hard for cancer genetics scientists to narrow down the culprit.
The research released on Friday also indicated that “clusters of seemingly disparate genes all work along the same pathways. So instead of today’s hunt for drugs that target a single gene, the idea is to target entire pathways that most patients share.” This could most closely resemble a mail carrier delivering a mail to a group mailbox at the end of a housing section versus each individual mailbox.
Dr. Phillip Febbo of Duke University’s Institute for Genome Sciences and Policy, said “This is the next wave. What’s really important is that finding those common elements within the landscape suggests there are therapeutic interventions that can help the whole group.” Over the past thirty years of lab work, scientists have never found more than a fraction of genetic alterations that cause any of the 200 diseases that spawn cancer. Various tumors require a different assortment of genetic changes to manifest and also to determine their
Different tumors require a different domino effect of genetic changes to arise, and to determine their gravity and the necessary treatments. Researchers have found missing genes, extra, overactive and underactive genes in their widespread look at human tumors.
The Associated Press report states, “The Hopkins teams found hundreds of genetic changes, including a particularly intriguing gene named IDH1. Twelve percent of glioblastoma patients, mostly young ones, harbored a mutated version that brought longer survival: a median of 3.8 years compared with the 1.1 years for patients without the mutation.”
To read more about this study, Cancer Genetics click here
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